Repeated USMLE Questions Step 1- 162

A 45 year-old man presents with progressive burning epigastric pain. He smokes and drinks alcohol socially. Physical examination, laboratory tests and imaging studies confirm the diagnosis of peptic ulcer. He is prescribed omeprazole.

What is the effect of this medication that improves this condition?

A-Anti-cholinergic effect

B-Inhibition of H+/K+ ATPase pump

C-Blocking of H2 receptor

D-Neutralization of gastric acid

E-Forming a layer to protect gastric mucosa


Answer:







Administration of omeprazole leads to irreversible inhibition of the H+/K+ ATPase pump in the parietal cell membrane. Other choices are mechanisms of action of other drugs also used in peptic ulcer medical treatment.

The correct answer is B